Janumet® 50/1000 mg Tablets in Pakistan

Janumet® 50/1000 mg is an oral prescription medicine used to help control blood glucose levels in adults with type 2 diabetes mellitus. It combines two antidiabetic medicines: sitagliptin and metformin hydrochloride.

Active Ingredients

Each 50/1000 mg tablet contains:

• Sitagliptin: 50 mg
• Metformin hydrochloride: 1000 mg
• Dosage form: Film-coated tablet
• Route: Oral

Uses

Janumet® is prescribed as part of a treatment plan for type 2 diabetes when diet, exercise, or other diabetes medicines do not provide adequate blood sugar control. It helps improve blood glucose regulation through the complementary effects of sitagliptin and metformin.

How Does Janumet® Work?

Sitagliptin is a DPP-4 inhibitor that helps increase the activity of incretin hormones, which can increase insulin release when blood glucose is elevated and reduce glucagon production.

Metformin helps lower glucose production by the liver and improves the body's sensitivity to insulin.

Strength & Presentation

• Brand: Janumet®
• Strength: 50 mg/1000 mg
• Ingredients: Sitagliptin + Metformin
• Form: Film-coated tablet
• Manufacturer/Marketer in Pakistan: The Searle Company Limited lists Janumet 50+1000 mg among its products.
• Pack: Searle lists a 14-tablet presentation in Pakistan.

Dosage & Administration

The dose should be determined by your doctor based on your blood glucose control, kidney function, current diabetes treatment, and other individual factors. Janumet should be taken exactly as prescribed and is generally taken with meals to help reduce gastrointestinal discomfort.

Do not change the dose or stop treatment without consulting your healthcare professional.

Possible Side Effects

Possible side effects may include:

• Nausea
• Diarrhea
• Stomach discomfort
• Vomiting
• Headache
• Metallic taste

Low blood sugar may occur particularly when Janumet is used together with insulin or certain other diabetes medicines.

Important Precautions

Tell your doctor if you have kidney or liver problems, pancreatitis, or vitamin B12 deficiency, or if you take other medicines for diabetes. Metformin-containing medicines require particular attention to kidney function.

Seek urgent medical attention for severe or persistent abdominal pain, serious allergic symptoms, or other unusual reactions.

Storage

Store the medicine according to the instructions on the package, generally in a cool, dry place below 30°C, protected from moisture and direct sunlight. Keep out of reach of children.

Availability in Pakistan

Janumet® 50/1000 mg is listed for the Pakistani market, and local pharmacy listings show a 14-tablet pack. Availability and retail prices can vary by pharmacy, location, and current stock.