Cyramza (Ramucirumab) 500mg/50 mL Injection in Pakistan

Cyramza 500mg/50 mL (10mg/mL) is a prescription anticancer medicine containing ramucirumab. It is a monoclonal antibody used in the treatment of certain types of cancer. It works by targeting vascular endothelial growth factor receptor 2 (VEGFR-2), helping to inhibit the formation of new blood vessels that supply tumors.

Product Information

Uses of Cyramza Injection

Cyramza may be prescribed for certain advanced cancers, depending on the patient's diagnosis and previous treatment. Approved uses include the following:

• Stomach cancer: Advanced or metastatic gastric or gastroesophageal junction cancer.

• Non-small cell lung cancer: Specific cases, sometimes in combination with other targeted medicines or chemotherapy.

• Colorectal cancer: Metastatic colorectal cancer following certain previous treatments.

• Liver cancer: Hepatocellular carcinoma in selected patients with an alpha-fetoprotein (AFP) level of at least 400 ng/mL who have previously received sorafenib.

How Does Cyramza Work?

Ramucirumab blocks VEGFR-2, a receptor involved in the development of blood vessels. By interfering with this pathway, it can reduce the blood supply that tumors need to grow. It is a targeted cancer therapy and may be used alone or alongside other anticancer medicines.

Dosage and Administration

• Administered as an intravenous (IV) infusion by trained healthcare professionals.

• The dose and treatment schedule depend on the cancer type, body weight, treatment combination, and patient's condition.

• It must not be self-administered.

• Treatment should be prescribed and monitored by an oncologist.

Possible Side Effects

Potential side effects include:

• High blood pressure

• Fatigue and weakness

• Diarrhea

• Nosebleeds or other bleeding

• Protein in the urine

• Infusion-related reactions

Important safety warning: Cyramza can cause serious bleeding, gastrointestinal perforation, blood clots, and impaired wound healing. Seek urgent medical attention for severe bleeding, sudden severe abdominal pain, chest pain, or difficulty breathing.

Storage Instructions

Store refrigerated at 2–8°C (36–46°F), protect from light, and do not freeze. Follow the manufacturer's instructions and ensure appropriate cold-chain handling during transport.