Ofev® 150 mg (Nintedanib) Soft Capsules in Pakistan

Product Overview

Ofev® 150 mg Soft Capsules contain nintedanib, an antifibrotic medicine used to slow the progression of certain chronic fibrosing lung diseases. It is a prescription medicine intended to be used under the supervision of a specialist.

Active Ingredient

• Brand: Ofev®
• Active ingredient: Nintedanib
• Strength: 150 mg
• Dosage form: Soft gelatin capsule
• Route: Oral
• Pack size: Varies by market

Each capsule contains 150 mg nintedanib (as nintedanib esilate).

Uses

Ofev® 150 mg may be prescribed for adults with:

• Idiopathic pulmonary fibrosis (IPF)
• Chronic fibrosing interstitial lung diseases (ILDs) with a progressive phenotype
• Systemic sclerosis-associated interstitial lung disease (SSc-ILD)

The approved indications can vary by country and patient age.

How Does Ofev® Work?

Nintedanib is a tyrosine kinase inhibitor that blocks signalling pathways involved in the development of fibrosis. By inhibiting these pathways, it helps slow the rate of decline in lung function in patients with certain progressive fibrosing lung diseases.

Dosage & Administration

For many adult indications, the recommended dose is 150 mg twice daily, approximately 12 hours apart, taken with food. The capsules should be swallowed whole with liquid and should not be chewed, opened, or crushed.

The appropriate dose may need adjustment depending on tolerability, liver function, and the patient's medical condition. Do not change the dose without your doctor's advice.

Important Precautions

Before starting Ofev®, doctors generally assess liver function. Nintedanib can cause liver-enzyme elevations and other adverse effects.

Tell your doctor if you have liver disease, bleeding problems, cardiovascular disease, or are taking medicines that may affect bleeding risk.

Possible Side Effects

Common side effects may include:

• Diarrhea
• Nausea
• Abdominal pain
• Vomiting
• Reduced appetite
• Weight loss
• Increased liver enzymes

Persistent or severe diarrhea, significant abdominal pain, unusual bleeding, or signs of liver problems should be reported to a healthcare professional promptly.

Pregnancy & Breastfeeding

Nintedanib may cause fetal harm. Women who could become pregnant should discuss appropriate pregnancy precautions with their doctor before and during treatment. Your healthcare professional can also advise whether breastfeeding is appropriate while taking Ofev®.

Storage

Store Ofev® according to the manufacturer's instructions and keep it in its original packaging, protected from moisture. Keep the medicine out of reach of children.

Availability in Pakistan

Ofev® is a specialist prescription medicine and availability can depend on registration, importer/distributor stock, and pharmacy supply. For genuine medicines, patients should purchase through licensed pharmacies and authorized medicine suppliers.

For confirmation of current availability and authorized supply channels in Pakistan, the relevant manufacturer/distributor should be contacted directly.

Availability Across Pakistan

Ofev® may be sourced through specialist pharmacies and medicine suppliers in Karachi, Lahore, Islamabad, Rawalpindi, Peshawar, Multan, Faisalabad, Gujranwala, Hyderabad, Sialkot, Bahawalpur, Sukkur, Larkana and other major cities, subject to current stock.

Prescription Information

Ofev® 150 mg is a prescription medicine. Treatment should be initiated and monitored by a physician experienced in managing interstitial lung disease or the relevant underlying condition.