Xolair® 150 mg/mL Injection (Omalizumab) in Pakistan

Xolair® 150 mg/mL Injection contains omalizumab, a humanized monoclonal antibody and anti-IgE biologic medicine. It is used for certain allergic and inflammatory conditions, including severe allergic asthma and chronic spontaneous urticaria (hives), according to the applicable prescribing information.

Active Ingredient

• Brand: Xolair®
• Generic name: Omalizumab
• Strength: 150 mg/mL
• Dosage form: Solution for injection
• Route: Subcutaneous injection
• Presentation: 150 mg single-dose pre-filled syringe/pen or vial, depending on the market presentation.

Uses

Xolair® may be prescribed for:

• Severe persistent allergic asthma
• Chronic spontaneous urticaria (chronic hives) that remains inadequately controlled with standard treatment
• Certain other approved allergic conditions, depending on the patient's age and local regulatory indications.

How Does Xolair® Work?

Omalizumab binds to immunoglobulin E (IgE) in the bloodstream. By reducing free IgE and its interaction with immune cells involved in allergic reactions, Xolair helps reduce the allergic inflammatory response.

Dosage & Administration

The required dose and frequency depend on the medical condition, body weight, and other clinical factors. For allergic asthma, dosing is determined using body weight and baseline IgE levels. For other indications, different dosing schedules may apply.

Xolair is administered subcutaneously by a healthcare professional or, where appropriate, by a patient/caregiver after receiving proper training.

Important Safety Information

Xolair can cause serious allergic reactions, including anaphylaxis, which can occur after an injection. Patients should therefore follow their healthcare provider's instructions regarding administration and observation.

Xolair is not intended for the immediate treatment of an acute asthma attack or other sudden breathing emergency.

Possible Side Effects

Possible side effects may include:

• Injection-site pain, redness, swelling or itching
• Headache
• Joint pain
• Dizziness
• Fatigue
• Upper respiratory tract symptoms

Serious allergic reactions are uncommon but can be life-threatening and require immediate medical attention.

Storage

Xolair is a cold-chain biological medicine. The 150 mg/mL pre-filled presentation should generally be refrigerated at 2°C–8°C, protected from light and not frozen. Follow the specific storage instructions supplied with the product.

Availability in Pakistan

Xolair 150 mg/mL (omalizumab) is listed in Pakistani medicine databases under Novartis Pharma (Pak) Ltd. A Pakistani pharmaceutical database lists the 150 mg/mL injection with a 1-vial presentation.

Availability Across Pakistan

Xolair may be sourced through specialist pharmacies and medicine suppliers in Lahore, Karachi, Islamabad, Bahawalpur, Peshawar, Multan, Gujranwala, Rawalpindi, Hyderabad, Faisalabad, Larkana, Sukkur, Sialkot, and other major cities of Pakistan, subject to current stock and cold-chain requirements. Pakistani pharmacy listings also identify it as a temperature-sensitive product requiring refrigerated storage.

Prescription Information

Xolair® is a specialist prescription biologic medicine. It should be obtained from a licensed pharmacy and used under the supervision of a qualified healthcare professional.